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5-HT reuptake

" in MedChemExpress (MCE) Product Catalog:

41

Inhibitors & Agonists

9

Isotope-Labeled Compounds

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-B1287
    Citalopram hydrobromide
    Maximum Cited Publications
    6 Publications Verification

    (±)-Citalopram hydrobromide; Lu 10-171

    		 Serotonin Transporter Autophagy Neurological Disease Cancer
    Citalopram hydrobromide is a selective serotonin reuptake inhibitor (SSRI). Citalopram hydrobromide inhibits 5-HT uptake into synaptosomes with an IC50 of 1.8 nM. Citalopram hydrobromideinhibits the 5-HT uptake in rabbit blood platelets with an IC50 of 14 nM. Antidepressant effect .
    Citalopram hydrobromide
  • HY-B0457
    Clomipramine hydrochloride
    1 Publications Verification

    Chlorimipramine hydrochloride; G-34586 hydrochloride; NSC-169865 hydrochloride

    		 Serotonin Transporter Neurological Disease
    Clomipramine (Chlorimipramine) hydrochloride is a potent 5-HT reuptake blocker with the IC50 value of 1.5 nM. Clomipramine hydrochloride is a tricyclic antidepressant that can be used for the research of depression and obsessive compulsive disorder (OCD) .
    Clomipramine hydrochloride
  • HY-B0457A
    Clomipramine
    1 Publications Verification

    Chlorimipramine; G-34586; NSC-169865

    		 Serotonin Transporter Neurological Disease
    Clomipramine (Chlorimipramine) is a potent 5-HT reuptake blocker with the IC50 value of 1.5 nM. Clomipramine is a tricyclic antidepressant that can be used for the research of depression and obsessive compulsive disorder (OCD) .
    Clomipramine
  • HY-160656
    5-HT/NA Reuptake inhibitor-1

    		5-HT Receptor Others Neurological Disease
    5-HT/NA Reuptake inhibitor-1 (compound 9) is a selective dual 5-HT and NA reuptake inhibitor with IC50 of 660 nM and 70 nM respectively. . 5-HT/NA Reuptake inhibitor-1 has good in vitro human metabolic stability, hERG selectivity and passive membrane permeability .
    <em>5-HT</em>/NA <em>Reuptake</em> inhibitor-1
  • HY-17032A
    Indeloxazine hydrochloride

    YM-08054

    		 5-HT Receptor Neurological Disease
    Indeloxazine hydrochloride is a 5-HT receptor and norepinephrine (NE) reuptake inhibitor. Indeloxazine hydrochloride is an antidepressant and cerebral activator .
    Indeloxazine hydrochloride
  • HY-W011235
    Norfluoxetine hydrochloride

    		5-HT Receptor Calcium Channel Drug Metabolite Neurological Disease
    Norfluoxetine hydrochloride is an active N-demethylated metabolite of Fluoxetine. Fluoxetine is a selective serotonin (5-HT) reuptake inhibitor that is metabolized to Norfluoxetine hydrochloride by cytochrome P450 (CYP) 2D6, CYP2C19, and CYP3A4. Norfluoxetine hydrochloride inhibits 5-HT uptake and inhibits CaV3.3 T current (IC50 = 5 μM). Norfluoxetine hydrochloride has anticonvulsant activity .
    Norfluoxetine hydrochloride
  • HY-B0196
    Venlafaxine
    1 Publications Verification

    Wy 45030

    		 Serotonin Transporter Neurological Disease Cancer
    Venlafaxine (Wy 45030) is an orally active, potent serotonin (5-HT)/norepinephrine (NE) reuptake dual inhibitor. Venlafaxine is an antidepressant .
    Venlafaxine
  • HY-B0196A
    Venlafaxine hydrochloride
    1 Publications Verification

    Wy 45030 hydrochloride

    		 Serotonin Transporter Neurological Disease Cancer
    Venlafaxine hydrochloride (Wy 45030 hydrochloride) is an orally active, potent serotonin (5-HT)/norepinephrine (NE) reuptake dual inhibitor. Venlafaxine is an antidepressant .
    Venlafaxine hydrochloride
  • HY-129985
    Clovoxamine

    DU23811

    		 Serotonin Transporter 5-HT Receptor Neurological Disease
    Clovoxamine (DU23811) (Compound 35) has binding affinity for serotonin transporter (SERT) (Ki: 61 nM). Clovoxamine is a 5-HT and norepinephrine reuptake (NE) re-uptake inhibitor. Clovoxamine is an antidepressant .
    Clovoxamine
  • HY-B1287R
    Citalopram hydrobromide (Standard)

    (±)-Citalopram hydrobromide(Standard); Lu 10-171 (Standard)

    		 Serotonin Transporter Autophagy Neurological Disease Cancer
    Citalopram (hydrobromide) (Standard) is the analytical standard of Citalopram (hydrobromide). This product is intended for research and analytical applications. Citalopram hydrobromide is a selective serotonin reuptake inhibitor (SSRI). Citalopram hydrobromide inhibits 5-HT uptake into synaptosomes with an IC50 of 1.8 nM. Citalopram hydrobromideinhibits the 5-HT uptake in rabbit blood platelets with an IC50 of 14 nM. Antidepressant effect .
    Citalopram hydrobromide (Standard)
  • HY-19417A
    Wf-516

    		Serotonin Transporter 5-HT Receptor Neurological Disease
    Wf-516 is an inhibitor of 5-HT reuptake, and an antagonist of 5-HT1A and 5-HT2A receptors, with Ki of 5 nM and 40 nM for 5-HT1A receptor and 5-HT2A receptor in humans, respectively, and has potent antidepressant activity.
    Wf-516
  • HY-131284
    (S)-Dehydro Venlafaxine

    		Drug Metabolite Others
    (S)-Dehydro Venlafaxine is an inactive S-enantiomer of Dehydro Venlafaxine. Dehydro Venlafaxine is an impurity of Venlafaxine hydrochloride. Venlafaxine hydrochloride (Wy 45030 hydrochloride) is a potent serotonin (5-HT) / norepinephrine (NE) reuptake dual inhibitor .
    (S)-Dehydro Venlafaxine
  • HY-19417
    Wf-516 hydrochloride

    		Serotonin Transporter 5-HT Receptor Neurological Disease
    Wf-516 hydrochloride is an inhibitor of 5-HT reuptake, and an antagonist of 5-HT1A and 5-HT2A receptors, with Ki of 5 nM and 40 nM for 5-HT1A receptor and 5-HT2A receptor in humans, respectively.Wf-516 hydrochloride has potent antidepressant activity.
    Wf-516 hydrochloride
  • HY-B0457S1
    Clomipramine-d6 hydrochloride

    Chlorimipramine-d6 (hydrochloride); G-34586-d6 (hydrochloride); NSC-169865-d6 (hydrochloride)

    		 Serotonin Transporter Neurological Disease
    Clomipramine-d6 (hydrochloride) is the deuterium labeled Clomipramine hydrochloride. Clomipramine (Chlorimipramine) hydrochloride is a potent 5-HT reuptake blocker with the IC50 value of 1.5 nM. Clomipramine hydrochloride is a tricyclic antidepressant that can be used for the research of depression and obsessive compulsive disorder (OCD)[1].
    Clomipramine-d6 hydrochloride
  • HY-B0527A
    Amitriptyline hydrochloride
    3 Publications Verification

    		 Serotonin Transporter 5-HT Receptor Histamine Receptor mAChR Adrenergic Receptor Sodium Channel Trk Receptor Neurological Disease Cancer
    Amitriptyline hydrochloride is an inhibitor of serotonin reuptake transporter (SERT) and noradrenaline reuptake transporter (NET), with Kis of 3.45 nM and 13.3 nM for human SERT and NET, respectively. Amitriptyline hydrochloride also weakly binds to dopamine reuptake transporter (DAT) with a Ki of 2.58 μM. Amitriptyline hydrochloride also inhibits adrenergic, muscarinic, histamine and 5-HT receptors. Amitriptyline hydrochloride is a TrkA and TrkB receptors agonist with potent neurotrophic activity. Amitriptyline hydrochloride has antidepressant activity .
    Amitriptyline hydrochloride
  • HY-B0527AS
    Amitriptyline-d6 hydrochloride

    		Serotonin Transporter 5-HT Receptor Histamine Receptor mAChR Adrenergic Receptor Sodium Channel Trk Receptor Neurological Disease
    Amitriptyline-d6 (hydrochloride) is the deuterium labeled Amitriptyline hydrochloride. Amitriptyline hydrochloride is an inhibitor of serotonin reuptake transporter (SERT) and noradrenaline reuptake transporter (NET), with Kis of 3.45 nM and 13.3 nM for human SERT and NET, respectively. Amitriptyline hydrochloride also weakly binds to dopamine reuptake transporter (DAT) with a Ki of 2.58 μM. Amitriptyline hydrochloride also inhibits adrenergic, muscarinic, histamine and 5-HT receptors. Amitriptyline hydrochloride is a TrkA and TrkB receptors agonist with potent neurotrophic activity. Amitriptyline hydrochloride has antidepressant activity[1][2][3].
    Amitriptyline-d6 hydrochloride
  • HY-135096
    Amitriptyline-d3 hydrochloride

    		Serotonin Transporter 5-HT Receptor Histamine Receptor mAChR Adrenergic Receptor Sodium Channel Trk Receptor Neurological Disease
    Amitriptyline-d3 hydrochloride is the deuterium labeled Amitriptyline (hydrochloride). Amitriptyline hydrochloride is an inhibitor of serotonin reuptake transporter (SERT) and noradrenaline reuptake transporter (NET), with Kis of 3.45 nM and 13.3 nM for human SERT and NET, respectively. Amitriptyline hydrochloride also weakly binds to dopamine reuptake transporter (DAT) with a Ki of 2.58 μM. Amitriptyline hydrochloride also inhibits adrenergic, muscarinic, histamine and 5-HT receptors. Amitriptyline hydrochloride is a TrkA and TrkB receptors agonist with potent neurotrophic activity. Amitriptyline hydrochloride has antidepressant activity .
    Amitriptyline-d3 hydrochloride
  • HY-B0457S2
    Clomipramine-13C,d3 hydrochloride

    Chlorimipramine-13C,d3 hydrochloride; G-34586-13C,d3 hydrochloride; NSC-169865-13C,d3 hydrochloride

    		 Isotope-Labeled Compounds Serotonin Transporter Neurological Disease
    Clomipramine- 13C,d3 (hydrochloride) is the 13C- and deuterium labeled Clomipramine (hydrochloride). Clomipramine (Chlorimipramine) hydrochloride is a potent 5-HT reuptake blocker with the IC50 value of 1.5 nM. Clomipramine hydrochloride is a tricyclic antidepressant that can be used for the research of depression and obsessive compulsive disorder (OCD)[1].
    Clomipramine-13C,d3 hydrochloride
  • HY-17385
    Atomoxetine hydrochloride
    3 Publications Verification

    Tomoxetine hydrochloride; (R)-Tomoxetine hydrochloride; LY 139603

    		 Adrenergic Receptor Serotonin Transporter Sodium Channel Neurological Disease Cancer
    Atomoxetine (Tomoxetine) hydrochloride is a selective noradrenaline reuptake inhibitor with Ki values of 5 nM, 77 nM and 1451 nM for norepinephrine (NE), serotonin (5-HT) and dopamine (DA) transporters, respectively. Atomoxetine hydrochloride is a potent Na + channels (VGSCs) blocker. Atomoxetine hydrochloride can be used for attention-deficit hyperactivity disorder (ADHD) research .
    Atomoxetine hydrochloride
  • HY-B0527AR
    Amitriptyline hydrochloride (Standard)

    		Serotonin Transporter 5-HT Receptor Histamine Receptor mAChR Adrenergic Receptor Sodium Channel Trk Receptor Neurological Disease Cancer
    Amitriptyline (hydrochloride) (Standard) is the analytical standard of Amitriptyline (hydrochloride). This product is intended for research and analytical applications. Amitriptyline hydrochloride is an inhibitor of serotonin reuptake transporter (SERT) and noradrenaline reuptake transporter (NET), with Kis of 3.45 nM and 13.3 nM for human SERT and NET, respectively. Amitriptyline hydrochloride also weakly binds to dopamine reuptake transporter (DAT) with a Ki of 2.58 μM. Amitriptyline hydrochloride also inhibits adrenergic, muscarinic, histamine and 5-HT receptors. Amitriptyline hydrochloride is a TrkA and TrkB receptors agonist with potent neurotrophic activity. Amitriptyline hydrochloride has antidepressant activity .
    Amitriptyline hydrochloride (Standard)
  • HY-119209
    Nefazodone
    1 Publications Verification

    		 5-HT Receptor Cytochrome P450 Neurological Disease Inflammation/Immunology
    Nefazodone is an orally active phenylpiperazine antidepressant. Nefazodone can potently and selectively block postsynaptic 5-HT2A receptors, and moderately inhibit 5-HT and noradrenaline reuptake. Nefazodone can also relieve the adverse effects of stress on the the immune system of mice. Nefazodone has a high affinity for CYP3A4 isoenzyme, which indicates that it has certain risk of agent-agent interaction .
    Nefazodone
  • HY-W061043
    DOV-216,303

    		Serotonin Transporter Dopamine Transporter Neurological Disease
    DOV-216,303 is an antidepressant compound. DOV-216,303 inhibits the reuptake of norepinephrine (NE), serotonin (5‐HT), and dopamine (DA), with IC50 values of 14 nM, 20 nM and 78 nM for hSERT, hNET and hDAT, respectively. DOV-216,303 increases monoamine release in the prefrontal cortex of olfactory bulbectomized (OBX) rats .
    DOV-216,303
  • HY-107370
    Atomoxetine

    Tomoxetine; (R)-Tomoxetine

    		 Serotonin Transporter Sodium Channel Neurological Disease
    Atomoxetine (Tomoxetine) is a selective noradrenaline reuptake inhibitor with Ki values of 5, 77 and 1451 nM for norepinephrine (NE), serotonin (5-HT) and dopamine (DA) transporters, respectively. Atomoxetine (Tomoxetine) increases of DAEX and NEEX in the PFC and enhances catecholaminergic neurotransmission. Atomoxetine (Tomoxetine) is a potent Na + channels (VGSCs) blocker. Atomoxetine (Tomoxetine) can be used for attention-deficit hyperactivity disorder (ADHD) research .
    Atomoxetine
  • HY-101755
    Tedatioxetine hydrobromide

    Lu AA24530 hydrobromide

    		 5-HT Receptor Adrenergic Receptor Neurological Disease Endocrinology
    Tedatioxetine (Lu AA24530) hydrobromide acts as a serotonin and norepinephrine (NE)-preferring triple reuptake inhibitor (TRI) and 5-HT2A, 5-HT2C, 5-HT3 and α1A-adrenergic receptor antagonist
    . ,
    Tedatioxetine hydrobromide
  • HY-14261S
    Vilazodone-d8

    		5-HT Receptor Serotonin Transporter Neurological Disease
    Vilazodone-d8 is the a deuterium labeled vilazodone, which is a combined serotonin specific reuptake inhibitor (SSRI) and 5-HT1A receptor partial agonist.
    Vilazodone-d8
  • HY-W380450
    Viloxazine

    Viloxazin; Emovit

    		 5-HT Receptor Adrenergic Receptor Neurological Disease
    Viloxazine (Viloxazin) is a norepinephrine reuptake inhibitor, also a potent 5-HT2C agonist and 5-HT2B antagonist with an EC50 of 32 μM and an IC50 of 27 μM for 5-HT2C and 5-HT2B, respectively. The mechanism of action of Viloxazine predominantly involves serotonergic and noradrenergic pathways. Viloxazine can be used for researching depression .
    Viloxazine
  • HY-10792A
    Eplivanserin (mixture)

    SR-46349 (mixture)

    		 Serotonin Transporter 5-HT Receptor Neurological Disease
    Eplivanserin mixture (SR-46349 mixture) is a selective serotonin reuptake inhibitor and a 5-HT2A receptor antagonist, extracted from patent WO 2005/002578 A1 .
    Eplivanserin (mixture)
  • HY-125784
    Viloxazine hydrochloride

    Viloxazin hydrochloride; Emovit hydrochloride

    		 Others Neurological Disease
    Viloxazine hydrochloride is the hydrochloride salt form of Viloxazine (HY-W380450). Viloxazine (Viloxazin) hydrochloride is a norepinephrine reuptake inhibitor and a potent 5-HT2C agonist agent and 5-HT2B antagonist, EC50 for 5-HT2C b> is 32 μM, and the IC50 for 5-HT2B is 27 μM. Viloxazine hydrochloride's mechanism of action primarily involves serotonergic and noradrenergic pathways. Viloxazine hydrochloride is used in antidepressant research .
    Viloxazine hydrochloride
  • HY-32329
    Setiptiline

    Org-8282

    		 5-HT Receptor Adrenergic Receptor Neurological Disease
    Setiptiline (Org-8282) is a serotonin receptor antagonist. Setiptiline is a tetracyclic antidepressant (TeCA) which acts as a noradrenergic and specific serotonergic antidepressant (NaSSA). Setiptiline acts as a norepinephrine reuptake inhibitor, α2-adrenergic receptor antagonist, and serotonin receptor antagonist, likely at the 5-HT2A, 5-HT2C, and/or 5-HT3 subtypes, as well as an H1 receptor inverse agonist/antihistamine.
    Setiptiline
  • HY-32329A
    Setiptiline maleate

    MO-8282

    		 5-HT Receptor Neurological Disease
    Setiptiline maleate (MO-8282 maleate) is a serotonin receptor antagonist. Setiptiline maleate is a tetracyclic antidepressant (TeCA) which acts as a noradrenergic and specific serotonergic antidepressant (NaSSA). Setiptiline maleate acts as a norepinephrine reuptake inhibitor, α2-adrenergic receptor antagonist, and serotonin receptor antagonist, likely at the 5-HT2A, 5-HT2C, and/or 5-HT3 subtypes, as well as an H1 receptor inverse agonist/antihistamine .
    Setiptiline maleate
  • HY-B0196B
    (S)-Venlafaxine

    		Serotonin Transporter Cancer
    (S)-Venlafaxine is the (S)-configuration of Venlafaxine. Venlafaxine is an orally active, potent serotonin (5-HT)/norepinephrine (NE) reuptake dual inhibitor. Venlafaxine is an antidepressant agent .
    (S)-Venlafaxine
  • HY-32329S
    Setiptiline-d3

    		Isotope-Labeled Compounds 5-HT Receptor Adrenergic Receptor Neurological Disease
    Setiptiline-d3 is the deuterium labeled Setiptiline. Setiptiline (Org-8282) is a serotonin receptor antagonist. Setiptiline is a tetracyclic antidepressant (TeCA) which acts as a noradrenergic and specific serotonergic antidepressant (NaSSA). Setiptiline acts as a norepinephrine reuptake inhibitor, α2-adrenergic receptor antagonist, and serotonin receptor antagonist, likely at the 5-HT2A, 5-HT2C, and/or 5-HT3 subtypes, as well as an H1 receptor inverse agonist/antihistamine[1][2].
    Setiptiline-d3
  • HY-14262
    Vilazodone
    3 Publications Verification

    EMD 68843; SB659746A

    		 5-HT Receptor Serotonin Transporter Neurological Disease
    Vilazodone (EMD 68843; SB 659746A) is a potent, selective and orally active serotonin reuptake inhibitor (SSRI) and partial 5-HT1A receptor agonist. Vilazodone exhibits antidepressant efficacy in vivo can be used for the research of major depressive disorder (MDD) and affective disorders .
    Vilazodone
  • HY-B0196S
    Venlafaxine-d6

    		Isotope-Labeled Compounds Serotonin Transporter Neurological Disease
    Venlafaxine-d6 is the deuterium labeled Venlafaxine. Venlafaxine (Wy 45030) is an orally active, potent serotonin (5-HT)/norepinephrine (NE) reuptake dual inhibitor. Venlafaxine is an antidepressant[1].
    Venlafaxine-d6
  • HY-B0196AS1
    Venlafaxine-d6 hydrochloride

    Wy 45030-d6 (hydrochloride)

    		 Serotonin Transporter Neurological Disease
    Venlafaxine-d6 (hydrochloride) is the deuterium labeled Venlafaxine hydrochloride. Venlafaxine hydrochloride (Wy 45030 hydrochloride) is an orally active, potent serotonin (5-HT)/norepinephrine (NE) reuptake dual inhibitor. Venlafaxine is an antidepressant[1].
    Venlafaxine-d6 hydrochloride
  • HY-B0196AS
    Venlafaxine-d10 hydrochloride

    		Serotonin Transporter Neurological Disease
    Venlafaxine-d10 (hydrochloride) is the deuterium labeled Venlafaxine hydrochloride. Venlafaxine (Wy 45030) hydrochloride is an orally active, potent serotonin (5-HT)/norepinephrine (NE) reuptake dual inhibitor. Venlafaxine is an antidepressant[1][2].
    Venlafaxine-d10 hydrochloride
  • HY-B0196S1
    Venlafaxine-d6-1

    Wy 45030-d6-1

    		 Isotope-Labeled Compounds Serotonin Transporter Neurological Disease
    Venlafaxine-d6-1 is deuterium labeled Venlafaxine. Venlafaxine (Wy 45030) is an orally active, potent serotonin (5-HT)/norepinephrine (NE) reuptake dual inhibitor. Venlafaxine is an antidepressant[1].
    Venlafaxine-d6-1
  • HY-B0196AR
    Venlafaxine hydrochloride (Standard)

    Wy 45030 hydrochloride (Standard)

    		 Serotonin Transporter Neurological Disease Cancer
    Venlafaxine (hydrochloride) (Standard) is the analytical standard of Venlafaxine (hydrochloride). This product is intended for research and analytical applications. Venlafaxine hydrochloride (Wy 45030 hydrochloride) is an orally active, potent serotonin (5-HT)/norepinephrine (NE) reuptake dual inhibitor. Venlafaxine is an antidepressant .
    Venlafaxine hydrochloride (Standard)
  • HY-14472
    Tesofensine

    NS-2330

    		 Dopamine Transporter Serotonin Transporter Metabolic Disease
    Tesofensine (NS-2330) is a triple monoamine reuptake inhibitor inducing a potent inhibition of the re-uptake process in the synaptic cleft of the neurotransmitters dopamine (DA; IC50=6.5 nM), norepinephrine (NE;IC50=1.7 nM), and serotonin (5-HT;IC50=11 nM), and with potentials as an anti-obesity agent . Tesofensine is a CNS acting anti-obesity agent .
    Tesofensine
  • HY-14348
    GSK163090

    		5-HT Receptor Dopamine Receptor Neurological Disease
    GSK163090 is a potent, selective and orally active 5-HT1A/1B/1D receptor antagonist with pKi values of 9.4/8.5/9.7, respectively. GSK163090 inhibits the functional activity of serotonin reuptake transporter (SerT) with a pKi value of 6.1. GSK163090 has antidepressant and anxiolytic activities .
    GSK163090
  • HY-14794
    Dextromilnacipran

    (1R,2S)-milnacipran; F2696

    		 Serotonin Transporter Metabolic Disease
    Dextromilnacipran (F2696; (1R,2S)-milnacipran), an enantiomer of milnacipran, is a selective serotonin and norepinephrine (5-HT/NE) reuptake inhibitor. Dextromilnacipran also is a human alpha-adrenergic receptor antagonist, with an IC50 of 3.4 μM. (patent WO2013014263A1).
    Dextromilnacipran

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